Encapsulation of a cationic antimicrobial peptide into self-assembled polyion complex nano-objects enhances its antitumor properties

Antimicrobial peptides, a large class of molecules synthetized by various organisms as an innate defense against pathogens are more and used for their anticancer properties well. In order to overcome some limitations enhance therapeutic efficiency, the use delivery systems was taken into consideration. this study we describe original system antimicrobial peptides based on its physico-chemical properties, namely self-assembled polyion complexes (PIC) electrostatic interactions cationic peptide P6 with negatively charged double hydrophilic block copolymers, poly(ethylene oxide)-poly(acrylic acid) (PEO-PAA) in our study. The drug tested 3D human tumor HCT-116 spheroids. spheroid evolution cell viability were monitored at 24 48 h after treatment applied. Our demonstrates first time feasibility forming complex PIC that organization provides added value terms anti-tumor efficacy compared free form peptide.